< PrevNext > 73. Shire Dublin Share 2017 U.S.-Booked Air Volume: $57 millionPrimary Global TMC: BCDBiopharmaceutical company Shire launched 50 products in 25 countries in 2017, increased its pro forma product sales growth by 8 percent to $14.4 billion, an increase of over $1 billion. It invested $1.8 billion in R&D last year and in 2018 plans targeted investments in its manufacturing infrastructure, product launches and clinical pipeline. In 2017, it cut its carbon emissions, including those from business travel. As of the end of the year, it employed 23,044 in over 60 countries.